Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage

Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage

Allopregnanolone (APα), as a functional neurosteroid, exhibits the neuroprotective effect on neurodegenerative diseases such as Parkinson’s disease (PD) through γ-aminobutyric acid A receptor (GABAAR), but it has not been completely understood about its molecular mechanisms. In order to investigate...

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Bibliographic Details
Main Authors: Tongtong Wang, Xin Ye, Wei Bian, Zhichi Chen, Juanjuan Du, Mengyi Li, Peng Zhou, Huairui Cui, Yu-Qiang Ding, Shuangshuang Qi, Min Liao, Chenyou Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
allopregnanolone
γ-aminobutyric acid A receptor
tyrosine hydroxylase-positive cell
Ca2+/calmodulin-dependent protein kinase II δ3
brain-derived neurotrophic factor
SH-SY5Y neuronal cell line
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00569/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00569/full

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