Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer.

Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer.

Recognizing EGFR as key orchestrator of the metastatic process in colorectal cancer, but also the substantial heterogeneity of responses to anti-EGFR therapy, we examined the pattern of composite tumor kinase activities governed by EGFR-mediated signaling that might be implicated in development of m...

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Main Authors: Anne Hansen Ree, Annette Torgunrud Kristensen, Marie Grøn Saelen, Rik de Wijn, Hege Edvardsen, Jovana Jovanovic, Torveig Weum Abrahamsen, Svein Dueland, Kjersti Flatmark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511283?pdf=render

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http://europepmc.org/articles/PMC3511283?pdf=render

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