Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity

Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity

Cyclic nucleotide phosphodiesterases (PDEs) are the only enzymes that degrade the cyclic nucleotides cAMP and cGMP, and play a key role in modulating the amplitude and duration of the signal delivered by these two key intracellular second messengers. Defects in cyclic nucleotide signalling are known...

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Bibliographic Details
Main Authors: Marcella Brescia, Manuela Zaccolo
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
cAMP
cGMP
Compartmentalisation
Phosphodiesterases (PDEs)
PDE inhibitor
protein kinase A
signaling
Online Access:http://www.mdpi.com/1422-0067/17/10/1672

Internet

http://www.mdpi.com/1422-0067/17/10/1672

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