Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene.

Ezrin has been reported to be upregulated in many tumors and to participate in metastatic progression. No study has addressed epigenetic modification in the regulation of Ezrin gene expression, the importance of which is unknown. Here, we report that highly metastatic rhabdomyosarcoma (RMS) cells wi...

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Bibliographic Details
Main Authors: Yanlin Yu, Pingyao Zeng, Jingbo Xiong, Ziyang Liu, Shelley L Berger, Glenn Merlino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2938331?pdf=render