STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5

STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5

Summary: Loss of midbrain dopaminergic (mDA) neurons and their axons is central to Parkinson's disease (PD). Growth differentiation factor (GDF)5 is a potential neurotrophic factor for PD therapy. However, the molecular mediators of its neurotrophic action are unknown. Our proteomics analysis s...

Full description

Bibliographic Details
Main Authors:	Jayanth Anantha, Susan R. Goulding, Sean L. Wyatt, Ruth M. Concannon, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Series:	iScience
Subjects:	Molecular Biology Neuroscience Proteomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220306490

Similar Items

Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson’s disease
by: Susan R Goulding, et al.
Published: (2022-01-01)

The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease
by: Susan R Goulding, et al.
Published: (2020-01-01)

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling
by: Martina Mazzocchi, et al.
Published: (2019-09-01)

Neurotrophic factor therapy for Parkinson′s disease: past, present and future
by: Aideen M Sullivan, et al.
Published: (2016-01-01)

Regulation of neurite growth by tumour necrosis superfamily member RANKL
by: Humberto Gutierrez, et al.
Published: (2013-01-01)

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism
by: Arielle N. Valdez-Sinon, et al.
Published: (2020-05-01)

The role of the endocytic adapter protein numb in mature neurites of the retina
by: Cai, Ouhua
Published: (2011)

A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury
by: Vaibhav Patil, et al.
Published: (2021-03-01)

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features
by: Jon M. Madison, et al.
Published: (2021-01-01)

A novel function for neurexin and neuroligin family members in promoting neurite outgrowth
by: Murchison, Dana
Published: (2010)

Identification of 14-3-3 epsilon as a regulator of the neural apoptotic pathway for chronic-stress-induced depression
by: Yan Zhao, et al.
Published: (2021-02-01)

Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons
by: Rohit Kumar, et al.
Published: (2020-08-01)

Novel Neurotrophic and Neuroprotective Properties of the BBB-permeable Polysaccharide, Midi-GAGR
by: Makani, Vishruti
Published: (2015)

Editorial: The Role of Stem Cells, Epigenetics and MicroRNAs in Parkinson's Disease
by: Shane V. Hegarty, et al.
Published: (2020-06-01)

Neurotrophic factors and their receptors in the developing avian retina and its tectal target
by: Karlsson, Miriam
Published: (2001)

Enhanced Proteomics Resolves KCC2 as a Novel Therapeutic Target for Traumatic Brain Injury
by: Lizhnyak, Pavel N
Published: (2019)

Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease
by: Shane V Hegarty, et al.
Published: (2017-01-01)

The Epigenome as a therapeutic target for Parkinson's disease
by: Shane V Hegarty, et al.
Published: (2016-01-01)

Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles
by: Cassandra Collins, et al.
Published: (2017-09-01)

Inhibition of focal adhesion kinase promotes adult olfactory stem cell self-renewal and neuroregeneration via ciliary neurotrophic factor
by: Oliver, Joe, et al.
Published: (2018)

Disease modifying therapy for multiple system atrophy – Parkinsonian Type
by: Dwyer, Sean Sullivan
Published: (2018)

Bone Morphogenetic Protein Receptors in the Nervous System: Neurotrophic Functions with Emphasis on Catecholaminergic Neurons
by: Bengtsson, Henrik
Published: (2001)

Effect of genetic polymorphism of brain-derived neurotrophic factor and serotonin transporter on smoking phenotypes: A pilot study of Japanese participants
by: Masanori Ohmoto, et al.
Published: (2019-02-01)

Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells
by: Ryuji Owada, et al.
Published: (2020-09-01)

The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage
by: Martina Radić, et al.
Published: (2020-03-01)

Recent Developments in Data Independent Acquisition (DIA) Mass Spectrometry: Application of Quantitative Analysis of the Brain Proteome
by: Ka Wan Li, et al.
Published: (2020-12-01)

Brain-derived neurotrophic factor and mental disorders
by: Chin-Chuen Lin, et al.
Published: (2020-04-01)

Swap Straps
by: Jerina Y. Ramos, et al.
Published: (2014)

The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling
by: Laura McKelvey, et al.
Published: (2012-08-01)

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
by: Shane V. Hegarty, et al.
Published: (2017-08-01)

Using neurite orientation dispersion and density imaging and tracts constrained by underlying anatomy to differentiate between subjects along the Alzheimer's disease continuum
by: Zhang, Zannan
Published: (2019)

Sex Differences in Adolescent Methylphenidate Sensitization: Effects on Glial Cell-Derived Neurotrophic Factor and Brain-Derived Neurotrophic Factor
by: Roeding, Ross L., et al.
Published: (2014)

NME/NM23/NDPK and Histidine Phosphorylation
by: Kevin Adam, et al.
Published: (2020-08-01)

Inguinal groin strap
by: Ingrid Parry, et al.
Published: (2021-10-01)

Immunosignature of Alzheimer's Disease
Published: (2011)

Methylphenidate Conditioned Place Preference: Role of D1 Receptors and Brain-derived Neurotrophic Factor
by: Peterson, Daniel J., et al.
Published: (2013)

Fibrinolytic Proteins and Brain-Derived Neurotrophic Factor Modulation of Suprachiasmatic Nucleus Circadian Clock
by: Mou, Xiang
Published: (2010)

The Effects of Adolescent Methylphenidate Exposure on the Behavioral and Brain-Derived Neurotrophic Factor Response to Nicotine
by: Cummins, Elizabeth D., et al.
Published: (2017)

Reward boosts reinforcement-based motor learning
by: Pierre Vassiliadis, et al.
Published: (2021-07-01)

Regionalized choroid plexus-cerebrospinal fluid factors and effect of DNA Ligase IV deficiency in the developing mammalian brain
by: Lun, Melody
Published: (2016)