Trials to overcome drug resistance to EGFR and ALK targeted therapies - past, present and future

Molecularly targeted agents (MTAs) are changing the therapeutic landscape in advanced non-small cell lung cancer (NSCLC). Since the discovery of sensitizing mutations in the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) domain, clinical investigations have focused on...

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Bibliographic Details
Main Authors: Glenwood Dillon Goss, Johanna eSpaans
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00233/full