IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

Abstract Background Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in RA and influenced by MTX treatment. We aimed to further investigate if...

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Bibliographic Details
Main Authors: Susanna L. Lundström, Aase H. Hensvold, Dorothea Rutishauser, Lars Klareskog, A. Jimmy Ytterberg, Roman A. Zubarev, Anca I. Catrina
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Arthritis Research & Therapy
Subjects:
Immunoglobulin
Glycosylation
Rheumatoid arthritis
Methotrexate
Complement
Biomarker
Online Access:http://link.springer.com/article/10.1186/s13075-017-1389-7

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http://link.springer.com/article/10.1186/s13075-017-1389-7

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