A mathematical model of case-ascertainment bias: Applied to case-control studies nested within a randomized screening trial.

When some individuals are screen-detected before the beginning of the study, but otherwise would have been diagnosed symptomatically during the study, this results in different case-ascertainment probabilities among screened and unscreened participants, referred to here as lead-time-biased case-asce...

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Bibliographic Details
Main Authors: Rick J Jansen, Bruce H Alexander, Richard B Hayes, Anthony B Miller, Sholom Wacholder, Timothy R Church
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5858824?pdf=render