Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model.

Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model.

The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under hypothermic conditions is unknown. This study addres...

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Bibliographic Details
Main Authors: Jeanette E Villanueva, Ling Gao, Hong C Chew, Mark Hicks, Aoife Doyle, Min Ru Qui, Kumud K Dhital, Peter S Macdonald, Andrew Jabbour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6185861?pdf=render

Internet

http://europepmc.org/articles/PMC6185861?pdf=render

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