Tracing the Photoaddition of Pharmaceutical Psoralens to DNA
The psoralens 8‑methoxypsoralen (8‑MOP), 4,5′,8‑trimethylpsoralen (TMP) and 5‑methoxypsoralen (5‑MOP) find clinical application in PUVA (psoralen + UVA) therapy. PUVA treats skin diseases like psoriasis and atopic eczema. Psoralens target the DNA of cells. Upon photo-excitation psoralens bind to the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/22/5242 |