CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro

Fibrosis is a condition shared by numerous inflammatory diseases. Our incomplete understanding of the molecular mechanisms underlying fibrosis has severely hampered effective drug development. CXCL4 is associated with the onset and extent of fibrosis development in multiple inflammatory and fibrotic...

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Bibliographic Details
Main Authors: Sandra C. Silva-Cardoso, Weiyang Tao, Chiara Angiolilli, Ana P. Lopes, Cornelis P. J. Bekker, Abhinandan Devaprasad, Barbara Giovannone, Jaap van Laar, Marta Cossu, Wioleta Marut, Erik Hack, Rob J. de Boer, Marianne Boes, Timothy R. D. J. Radstake, Aridaman Pandit
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
CXCL4
dendritic cells
fibrosis
gene regulatory networks
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02149/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02149/full

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