Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

The many variants of human Ca2+/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme. CaMKII activity depends on the balance between activating and inhibitory autophosphorylati...

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Bibliographic Details
Main Authors: Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioglu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T Groves, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
single-molecule microscopy
CaMKII isoforms
autophosphorylation
flexible linker
phosphatase resistance
kinase activity
Online Access:https://elifesciences.org/articles/53670

Internet

https://elifesciences.org/articles/53670

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