Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer

Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer

In colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) are the most abundant component from the tumor microenvironment (TM). CAFs facilitate tumor progression by inducing angiogenesis, immune suppression and invasion, thus altering the organization/composition of the extracellular matrix (...

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Bibliographic Details
Main Authors: Glauben Landskron, Marjorie De la Fuente López, Karen Dubois-Camacho, David Díaz-Jiménez, Octavio Orellana-Serradell, Diego Romero, Santiago A. Sepúlveda, Christian Salazar, Daniela Parada-Venegas, Rodrigo Quera, Daniela Simian, María-Julieta González, Francisco López-Köstner, Udo Kronberg, Mario Abedrapo, Iván Gallegos, Héctor R. Contreras, Cristina Peña, Guillermo Díaz-Araya, Juan Carlos Roa, Marcela A. Hermoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
cancer associated fibroblasts
interleukin 33
desmoplasia
epithelial-mesenchymal transition
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01394/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01394/full

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