The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells

The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells

The sesquiterpenes alantolactone (ATL) and germacrone (GER) are potential anticancer agents of natural origin. Their toxicity and biological activity have been evaluated using the differentiated HepaRG (dHepaRG) cells, a hepatocyte-like model. The half-maximal inhibitory concentrations of cell viabi...

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Bibliographic Details
Main Authors: Tomáš Zárybnický, Petra Matoušková, Lenka Skálová, Iva Boušová
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Nutrients
Subjects:
alantolactone
germacrone
liver toxicity
metabolic dysregulation
HepaRG cells
Online Access:https://www.mdpi.com/2072-6643/12/6/1720

Internet

https://www.mdpi.com/2072-6643/12/6/1720

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