Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses.

Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses.

Most antiviral treatment options target the invading pathogen and unavoidably encounter loss of efficacy as the pathogen mutates to overcome replication restrictions. A good strategy for circumventing drug resistance, or for pathogens without treatment options, is to target host cell proteins that a...

Full description

Bibliographic Details
Main Authors: Marta J Gonzalez-Hernandez, Anupama Pal, Kofi E Gyan, Marie-Eve Charbonneau, Hollis D Showalter, Nicholas J Donato, Mary O'Riordan, Christiane E Wobus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3983190?pdf=render

Internet

http://europepmc.org/articles/PMC3983190?pdf=render

Similar Items