Searching for synergies: matrix algebraic approaches for efficient pair screening.

Functionally interacting perturbations, such as synergistic drugs pairs or synthetic lethal gene pairs, are of key interest in both pharmacology and functional genomics. However, to find such pairs by traditional screening methods is both time consuming and costly. We present a novel computational-e...

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Bibliographic Details
Main Authors: Philip Gerlee, Linnéa Schmidt, Naser Monsefi, Teresia Kling, Rebecka Jörnsten, Sven Nelander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3723843?pdf=render