Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells

Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells

Single prostate stem cells can generate stem and progenitor cells to form prostaspheres in 3D culture. Using a prostasphere-based label retention assay, we recently identified keratin 13 (<i>KRT13</i>)-enriched prostate stem cells at single-cell resolution, distinguishing them from daugh...

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Bibliographic Details
Main Authors: Wen-Yang Hu, Dan-Ping Hu, Lishi Xie, Larisa Nonn, Ranli Lu, Michael Abern, Toshihiro Shioda, Gail S. Prins
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
stem cells
keratin
RNA-seq
single cell
lineage hierarchy
Online Access:https://www.mdpi.com/1422-0067/22/15/8109

Internet

https://www.mdpi.com/1422-0067/22/15/8109

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