Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Many encoded gene products responsible for neurodevelopmental disorders (NDs) like autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and idiopathic generalized epilepsy (IGE) converge on networks controlling synaptic function. An increase in KCC2 (SLC12A5) Cl- trans...

Full description

Bibliographic Details
Main Authors: Nancy D Merner, Madison R Chandler, Cynthia eBourassa, Bo eLiang, Arjun R Khanna, Patrick eDion, Guy eRouleau, Kristopher eKahle
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Schizophrenia
autism
GABA
KCC2
Neurodevelopmental disorders
NKCC1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00386/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00386/full

Similar Items