Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains. However, the binding affinities between the PH domains a...

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Bibliographic Details
Main Authors: Zhe Chen, Steven Gutowski, Paul C. Sternweis
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340918300271