Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

Abstract Background Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose lowering effects in healthy volunteers. Methods The volunteers partici...

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Bibliographic Details
Main Authors: Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding, Wenzheng Ju
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
Mitiglinide
Pharmacodynamic
Pharmacokinetic
Pharmacokinetic–pharmacodynamics modeling
Plasma glucose
Online Access:http://link.springer.com/article/10.1186/s40360-017-0161-6

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http://link.springer.com/article/10.1186/s40360-017-0161-6

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