Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host

Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host

Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associated with cytoadherence of parasitized red blood ce...

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Bibliographic Details
Main Authors: Pollyanna Stephanie Gomes, Scott Tanghe, Julio Gallego-Delgado, Luciana Conde, Leonardo Freire-de-Lima, Ana Carolina Lima, Célio Geraldo Freire-de-Lima, Josué da Costa Lima Junior, Otacílio Moreira, Paulo Totino, Ana Rodriguez, Adriane Regina Todeschini, Alexandre Morrot
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
Plasmodium falciparum
glycobyology
cerebral malaria
treatment strategies
parasites
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00305/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00305/full

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