Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target

Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target

Acidity is a key player in cancer progression, modelling a microenvironment that prevents immune surveillance and enhances invasiveness, survival, and drug resistance. Here, we demonstrated in spheroids from osteosarcoma cell lines that the exposure to acidosis remarkably caused intracellular lipid...

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Bibliographic Details
Main Authors: Margherita Cortini, Andrea Armirotti, Marta Columbaro, Dario Livio Longo, Gemma Di Pompo, Elena Cannas, Alessandra Maresca, Costantino Errani, Alessandra Longhi, Alberto Righi, Valerio Carelli, Nicola Baldini, Sofia Avnet
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
osteosarcoma
tumor microenvironment
acidity
sphingolipid
sphingosine 1-phosphate
lipidomics
Online Access:https://www.mdpi.com/2072-6694/13/2/311

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https://www.mdpi.com/2072-6694/13/2/311

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