The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival and to induce pro-angiogenic factors. Hypoxia induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1 alph...

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Bibliographic Details
Main Authors: Peleg eRider, Irena eKaplanov, Marianna eRomzova, Liora eBernardis, Alex eBraiman, Elena eVoronov, Ron Nathan Apte
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Immunology
Subjects:
IL-1
DAMPs
Cytokines and inflammation
HIF-1α
Sterile Inflammation
alarmin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00290/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00290/full

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