Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance

Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance

Abstract Mitochondrial epigenetics is rising as intriguing notion for its potential involvement in aging and diseases, while the details remain largely unexplored. Here it is shown that among the 13 mitochondrial DNA (mtDNA) encoded genes, NADH‐dehydrogenase 6 (ND6) transcript is primarily decreased...

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Bibliographic Details
Main Authors: Ke Cao, Weiqiang Lv, Xueqiang Wang, Shanshan Dong, Xuyun Liu, Tielin Yang, Jie Xu, Mengqi Zeng, Xuan Zou, Daina Zhao, Qingqing Ma, Mu Lin, Jiangang Long, Weijin Zang, Feng Gao, Zhihui Feng, Jiankang Liu
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Advanced Science
Subjects:
DNA methyltransferase 1 (DNMT1)
insulin resistance
mitochondrial dysfunction
mitochondrial NADH‐dehydrogenase 6 (ND6)
obesity and type 2 diabetes mellitus (T2DM)
Online Access:https://doi.org/10.1002/advs.202004507

Internet

https://doi.org/10.1002/advs.202004507

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