Samovar: Single-Sample Mosaic Single-Nucleotide Variant Calling with Linked Reads
Summary: Linked-read sequencing enables greatly improves haplotype assembly over standard paired-end analysis. The detection of mosaic single-nucleotide variants benefits from haplotype assembly when the model is informed by the mapping between constituent reads and linked reads. Samovar evaluates h...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-08-01
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Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219301749 |