Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

Leishmaniases are neglected diseases that cause a large spectrum of clinical manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory response involve the phagocytosis of Leishmania and the parasite replication inside the macrophage phagolysosome. Melatonin, the dark...

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Bibliographic Details
Main Authors: Juliane Cristina Ribeiro Fernandes, Juliana Ide Aoki, Stephanie Maia Acuña, Ricardo Andrade Zampieri, Regina P. Markus, Lucile Maria Floeter-Winter, Sandra Marcia Muxel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
polyamine pathway
nitric oxide synthase
arginase 1
interleukin
mRNA-miRNA interaction
melatonin and Leishmania
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00060/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00060/full

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