The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species.

SARS-coronavirus (CoV) is a zoonotic agent derived from rhinolophid bats, in which a plethora of SARS-related, conspecific viral lineages exist. Whereas the variability of virulence among reservoir-borne viruses is unknown, it is generally assumed that the emergence of epidemic viruses from animal r...

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Bibliographic Details
Main Authors: Daniela Niemeyer, Kirstin Mösbauer, Eva M Klein, Andrea Sieberg, Robert C Mettelman, Anna M Mielech, Ronald Dijkman, Susan C Baker, Christian Drosten, Marcel A Müller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007296