Initial mutations direct alternative pathways of protein evolution.

Initial mutations direct alternative pathways of protein evolution.

Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that affect fitness) is a mechanism that can contribute to both scenarios. Epistasis can co...

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Bibliographic Details
Main Authors: Merijn L M Salverda, Eynat Dellus, Florien A Gorter, Alfons J M Debets, John van der Oost, Rolf F Hoekstra, Dan S Tawfik, J Arjan G M de Visser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3048372?pdf=render

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http://europepmc.org/articles/PMC3048372?pdf=render

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