PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.

Inflammatory cytokines play an important role in the pathogenesis of heart failure. We have recently found the cytokine TWEAK (tumor necrosis factor (TNF)-like weak inducer of apoptosis), a member of the TNF superfamily, to be increased in patients with cardiomyopathy and result in the development o...

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Bibliographic Details
Main Authors: Jianru Shi, Bingbing Jiang, Yiling Qiu, Jian Guan, Mohit Jain, Xin Cao, Michael Bauer, Lihe Su, Linda C Burkly, Teresa C Leone, Daniel P Kelly, Ronglih Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3546975?pdf=render