HMGB1 in inflammation and cancer
Abstract High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular c...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-08-01
|
| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-020-00950-x |
| id |
doaj-e2d3397b80f24d80a7a82153e7d9ef85 |
|---|---|
| record_format |
Article |
| spelling |
doaj-e2d3397b80f24d80a7a82153e7d9ef852020-11-25T03:43:33ZengBMCJournal of Hematology & Oncology1756-87222020-08-011311410.1186/s13045-020-00950-xHMGB1 in inflammation and cancerShumin Wang0Yi Zhang1Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou UniversityBiotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou UniversityAbstract High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression.http://link.springer.com/article/10.1186/s13045-020-00950-xHMGB1RAGETLRDAMPInflammationCancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shumin Wang Yi Zhang |
| spellingShingle |
Shumin Wang Yi Zhang HMGB1 in inflammation and cancer Journal of Hematology & Oncology HMGB1 RAGE TLR DAMP Inflammation Cancer |
| author_facet |
Shumin Wang Yi Zhang |
| author_sort |
Shumin Wang |
| title |
HMGB1 in inflammation and cancer |
| title_short |
HMGB1 in inflammation and cancer |
| title_full |
HMGB1 in inflammation and cancer |
| title_fullStr |
HMGB1 in inflammation and cancer |
| title_full_unstemmed |
HMGB1 in inflammation and cancer |
| title_sort |
hmgb1 in inflammation and cancer |
| publisher |
BMC |
| series |
Journal of Hematology & Oncology |
| issn |
1756-8722 |
| publishDate |
2020-08-01 |
| description |
Abstract High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression. |
| topic |
HMGB1 RAGE TLR DAMP Inflammation Cancer |
| url |
http://link.springer.com/article/10.1186/s13045-020-00950-x |
| work_keys_str_mv |
AT shuminwang hmgb1ininflammationandcancer AT yizhang hmgb1ininflammationandcancer |
| _version_ |
1724519138470133760 |