Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.

Bibliographic Details
Main Authors: Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, Chuan Su
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16035

Internet

https://doi.org/10.1038/ncomms16035

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