Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251

Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251

<p>Abstract</p> <p>Glioblastoma multiforme (GBM) carries a dismal prognosis primarily due to its aggressive proliferation in the brain regulated by complex molecular mechanisms. One promising molecular target in GBM is over-expressed basic fibroblast growth factor (bFGF), which has...

Full description

Bibliographic Details
Main Authors: Zhang Biao, Feng Xuequan, Xu Xinnv, Liu Jun, Wang Jinhuan
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
bFGF
STAT3
IL-6
Glioblastoma multiforme
Online Access:http://www.jeccr.com/content/30/1/80

Internet

http://www.jeccr.com/content/30/1/80

Similar Items