Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation

Spitzoid melanoma is a rare malignancy with histological characteristics similar to Spitz nevus. It has a diverse genetic background and in adults, a similarly grim clinical outcome as conventional malignant melanoma. We established a spitzoid melanoma cell line (PF130) from the pleural effusion sam...

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Bibliographic Details
Main Authors: Luca Hegedüs, Özlem Okumus, Elisabeth Livingstone, Marcell Baranyi, Ildikó Kovács, Balázs Döme, József Tóvári, Ágnes Bánkfalvi, Dirk Schadendorf, Clemens Aigner, Balázs Hegedüs
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
metastatic melanoma
spitzoid melanoma
targeted therapy
MEK mutation
MEK inhibitor
Online Access:https://www.mdpi.com/2072-6694/13/4/829

Internet

https://www.mdpi.com/2072-6694/13/4/829

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