Preferential Reactivity of Dipeptidyl Peptidase-IV Inhibitor-Associated Bullous Pemphigoid Autoantibodies to the Processed Extracellular Domains of BP180

Preferential Reactivity of Dipeptidyl Peptidase-IV Inhibitor-Associated Bullous Pemphigoid Autoantibodies to the Processed Extracellular Domains of BP180

Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies target the hemidesmosomal components BP180 and/or BP230 in basal keratinocytes. In BP, 80 to 90% of autoantibodies target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. Recent...

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Bibliographic Details
Main Authors: Yosuke Mai, Wataru Nishie, Kentaro Izumi, Hiroshi Shimizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
bullous pemphigoid
dipeptidyl peptidase-IV inhibitor
dipeptidyl peptidase-IV inhibitor-associated bullous pemphigoid
autoantibodies
IgG subclass
BP180
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01224/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01224/full

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