Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated

Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated

In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One of the hallmarks of kidney disease-related cardiovascular disease is intravascular macrophage inflammation, but the mechanism of the reaction with these toxins is not com...

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Bibliographic Details
Main Authors: Takuya Wakamatsu, Suguru Yamamoto, Toru Ito, Yoko Sato, Koji Matsuo, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Fumitake Gejyo, Ichiei Narita
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Toxins
Subjects:
uremic toxins
indoxyl sulfate
macrophage
aryl hydrocarbon receptor
nuclear factor-κB
inflammasome
atherosclerosis
cardiovascular disease
Online Access:http://www.mdpi.com/2072-6651/10/3/124

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http://www.mdpi.com/2072-6651/10/3/124

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