Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.

Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.

<h4>Background</h4>The mechanisms by which DNA damage triggers suppression of transcription of a large number of genes are poorly understood. DNA damage rapidly induces a release of the positive transcription elongation factor b (P-TEFb) from the large inactive multisubunit 7SK snRNP com...

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Bibliographic Details
Main Authors: Giuliana Napolitano, Stefano Amente, Virginia Castiglia, Barbara Gargano, Vera Ruda, Xavier Darzacq, Olivier Bensaude, Barbara Majello, Luigi Lania
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20574533/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20574533/?tool=EBI

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