Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with other cell types mediating repair is not fully understood. Here we demonstrated that cardiac Mφs increased the expression of Mmp14 (MT1-MMP)...

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Bibliographic Details
Main Authors: Laura Alonso-Herranz, Álvaro Sahún-Español, Ana Paredes, Pilar Gonzalo, Polyxeni Gkontra, Vanessa Núñez, Cristina Clemente, Marta Cedenilla, María Villalba-Orero, Javier Inserte, David García-Dorado, Alicia G Arroyo, Mercedes Ricote
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
macrophages
MT1-MMP
TGFB1
myocardial infarction
tissue remodeling
endothelial cells
Online Access:https://elifesciences.org/articles/57920

Internet

https://elifesciences.org/articles/57920

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