A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

<p>Abstract</p> <p>Background</p> <p>The Signal Transducer and Activator of Transcription 3 (STAT3) is activated in tumor cells, and STAT3-inhibitors are able to induce the death of those cells. Decoy oligodeoxynucleotides (dODNs), which bind to the DNA Binding Domain (...

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Bibliographic Details
Main Authors: Souissi Inès, Ladam Patrick, Cognet Jean AH, Le Coquil Stéphanie, Varin-Blank Nadine, Baran-Marszak Fanny, Metelev Valeri, Fagard Remi
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Molecular Cancer
Subjects:
Hairpin decoy oligodeoxynucleotide (hpdODN)
STAT3
STAT1
Colon carcinoma cell line
Online Access:http://www.molecular-cancer.com/content/11/1/12

Internet

http://www.molecular-cancer.com/content/11/1/12

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