Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Folate Deficiency Triggers the Abnormal Segregation of a Region With Large Cluster of CG-Rich Trinucleotide Repeats on Human Chromosome 2

Folate deficiency is associated with a broad range of human disorders, including anemia, fetal neural tube defects, age-associated dementia and several types of cancer. It is well established that a subgroup of rare fragile sites (RFSs) containing expanded CGG trinucleotide repeat (TNR) sequences di...

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Bibliographic Details
Main Authors: Lorenza Garribba, Ivan Vogel, Mads Lerdrup, Marisa M. Gonçalves Dinis, Liqun Ren, Ying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
aneuploidy
fluorodeoxyuridine
fragile site
FRAXA
nondisjunction
MiDAS
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.695124/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.695124/full

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