High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection.

High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection.

OBJECTIVE:The immune rejection mediated by CD4+ T cell and antigen presenting macrophages is the leading cause of corneal transplantation failure. Bone marrow-derived mesenchymal stem cells (BM-MSCs) possess robust immunomodulatory potentials, and have been shown by us and others to promote corneal...

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Bibliographic Details
Main Authors: Xiaoxiao Lu, Chenchen Chu, Xun Liu, Yichen Gao, Mianmian Wu, Fang Guo, Yahong Li, Chao Geng, Yue Huang, Yan Zhang, Shaozhen Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222515

Internet

https://doi.org/10.1371/journal.pone.0222515

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