Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease

Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases that causes problems related to brain function. To some extent it is understood on a molecular level how AD arises, however there are a lack of biomarkers that can be used for early diagnosis. Two popul...

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Bibliographic Details
Main Authors: Jason E. Miller, Manu K. Shivakumar, Younghee Lee, Seonggyun Han, Emrin Horgousluoglu, Shannon L. Risacher, Andrew J. Saykin, Kwangsik Nho, Dokyoon Kim, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Medical Genomics
Subjects:
Alternative splicing
Imaging genomics
Alzheimer’s disease
Whole genome sequencing
Rare variants
Online Access:http://link.springer.com/article/10.1186/s12920-018-0390-6

Internet

http://link.springer.com/article/10.1186/s12920-018-0390-6

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