Prior population immunity reduces the expected impact of CTL-inducing vaccines for pandemic influenza control.

Vaccines that trigger an influenza-specific cytotoxic T cell (CTL) response may aid pandemic control by limiting the transmission of novel influenza A viruses (IAV). We consider interventions with hypothetical CTL-inducing vaccines in a range of epidemiologically plausible pandemic scenarios. We est...

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Bibliographic Details
Main Authors: Kirsty J Bolton, James M McCaw, Lorena Brown, David Jackson, Katherine Kedzierska, Jodie McVernon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4374977?pdf=render