Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 in <i>Mycobacterium tuberculosis</i>

Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 in <i>Mycobacterium tuberculosis</i>

Cytochrome P450 monooxygenases (CYPs/P450s) are well known for their role in organisms’ primary and secondary metabolism. Among 20 P450s of the tuberculosis-causing <i>Mycobacterium tuberculosis</i> H37Rv, CYP128A1 is particularly important owing to its involvement in synthesizing electr...

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Bibliographic Details
Main Authors: Nokwanda Samantha Ngcobo, Zinhle Edith Chiliza, Wanping Chen, Jae-Hyuk Yu, David R. Nelson, Jack A. Tuszynski, Jordane Preto, Khajamohiddin Syed
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
cytochrome P450 monooxygenenases
CYP128A1
<i>Mycobacterium tuberculosis</i> H37Rv
tuberculosis
molecular dynamic simulations
azole drugs
Online Access:https://www.mdpi.com/1422-0067/21/14/4816

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https://www.mdpi.com/1422-0067/21/14/4816

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