NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15 p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have b...

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Bibliographic Details
Main Authors: Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2017-07-01
Series:Intestinal Research
Subjects:
NUDT15
FTO
Thiopurine
Leukopenia
Inflammatory bowel disease
Online Access:https://doi.org/10.5217/ir.2017.15.3.328

Internet

https://doi.org/10.5217/ir.2017.15.3.328

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