Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization

Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization

Deciphering protection mechanisms against Mycobacterium tuberculosis (Mtb) remains a critical challenge for the development of new vaccines and therapies. We analyze the phenotypic and transcriptomic profile in lung of a novel tuberculosis (TB) nanoparticle-based boosting mucosal vaccine Nano-FP1, w...

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Bibliographic Details
Main Authors: Amparo Martínez-Pérez, Ana Igea, Olivia Estévez, Catarina M. Ferreira, Egídio Torrado, António Gil Castro, Carmen Fernández, Anna-Lena Spetz, Lucille Adam, Moisés López González, Mahavir Singh, Rajko Reljic, África González-Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
nanovaccines
immune protection
lung infection
transcriptomic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.589863/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.589863/full

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