Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside
Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival r...
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doaj-e31a876f5681497c822d1919dac8aed32021-06-30T23:11:25ZengMDPI AGCancers2072-66942021-06-01132777277710.3390/cancers13112777Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to BedsideMd. Hafiz Uddin0Mohammed Najeeb Al-Hallak1Philip A. Philip2Ramzi M. Mohammad3Nerissa Viola4Kay-Uwe Wagner5Asfar S. Azmi6Departments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USADepartments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USAPancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.https://www.mdpi.com/2072-6694/13/11/2777pancreatic cancerbiomarkerexosomemicroRNA (miRNA)early diagnosisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Md. Hafiz Uddin Mohammed Najeeb Al-Hallak Philip A. Philip Ramzi M. Mohammad Nerissa Viola Kay-Uwe Wagner Asfar S. Azmi |
spellingShingle |
Md. Hafiz Uddin Mohammed Najeeb Al-Hallak Philip A. Philip Ramzi M. Mohammad Nerissa Viola Kay-Uwe Wagner Asfar S. Azmi Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside Cancers pancreatic cancer biomarker exosome microRNA (miRNA) early diagnosis prognosis |
author_facet |
Md. Hafiz Uddin Mohammed Najeeb Al-Hallak Philip A. Philip Ramzi M. Mohammad Nerissa Viola Kay-Uwe Wagner Asfar S. Azmi |
author_sort |
Md. Hafiz Uddin |
title |
Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside |
title_short |
Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside |
title_full |
Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside |
title_fullStr |
Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside |
title_full_unstemmed |
Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside |
title_sort |
exosomal microrna in pancreatic cancer diagnosis, prognosis, and treatment: from bench to bedside |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-06-01 |
description |
Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer. |
topic |
pancreatic cancer biomarker exosome microRNA (miRNA) early diagnosis prognosis |
url |
https://www.mdpi.com/2072-6694/13/11/2777 |
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