Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression

Abstract Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecu...

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Bibliographic Details
Main Authors: Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi, Mingyao Liu, Yihua Chen
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Advanced Science
Subjects:
breast cancer
cancer metabolism
pyruvate carboxylase
small molecule ZY‐444
Wnt/β‐catenin/Snail pathway
Online Access:https://doi.org/10.1002/advs.201903483

Internet

https://doi.org/10.1002/advs.201903483

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