LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

Objective: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and GH secretion and...

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Bibliographic Details
Main Authors: Kripa Shankar, Nathan P. Metzger, Omprakash Singh, Bharath K. Mani, Sherri Osborne-Lawrence, Salil Varshney, Deepali Gupta, Sean B. Ogden, Shota Takemi, Corine P. Richard, Karabi Nandy, Chen Liu, Jeffrey M. Zigman
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
LEAP2
Ghrelin
Growth hormone
Food intake
GHSR
Body weight homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001745

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http://www.sciencedirect.com/science/article/pii/S2212877821001745

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