Liraglutide Inhibits Endothelial-to-Mesenchymal Transition and Attenuates Neointima Formation after Endovascular Injury in Streptozotocin-Induced Diabetic Mice

Liraglutide Inhibits Endothelial-to-Mesenchymal Transition and Attenuates Neointima Formation after Endovascular Injury in Streptozotocin-Induced Diabetic Mice

Hyperglycaemia causes endothelial dysfunction, which is the initial process in the development of diabetic vascular complications. Upon injury, endothelial cells undergo an endothelial-to-mesenchymal transition (EndMT), lose their specific marker, and gain mesenchymal phenotypes. This study investig...

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Bibliographic Details
Main Authors: Tzu-Hsien Tsai, Chien-Ho Lee, Cheng-I Cheng, Yen-Nan Fang, Sheng-Ying Chung, Shyh-Ming Chen, Cheng-Jei Lin, Chiung-Jen Wu, Chi-Ling Hang, Wei-Yu Chen
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
endothelial-mesenchymal transition
hyperglycaemia
liraglutide
neointima formation
Online Access:https://www.mdpi.com/2073-4409/8/6/589

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https://www.mdpi.com/2073-4409/8/6/589

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