ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation

Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development dat...

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Main Authors:	Mette Bentsen, Philipp Goymann, Hendrik Schultheis, Kathrin Klee, Anastasiia Petrova, René Wiegandt, Annika Fust, Jens Preussner, Carsten Kuenne, Thomas Braun, Johnny Kim, Mario Looso
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18035-1

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spelling	doaj-e3286bfee3c34ca8982de7e68a99c0a22021-08-29T11:39:26ZengNature Publishing GroupNature Communications2041-17232020-08-0111111110.1038/s41467-020-18035-1ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activationMette Bentsen0Philipp Goymann1Hendrik Schultheis2Kathrin Klee3Anastasiia Petrova4René Wiegandt5Annika Fust6Jens Preussner7Carsten Kuenne8Thomas Braun9Johnny Kim10Mario Looso11Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchGerman Centre for Cardiovascular Research (DZHK), Partner Site Rhine-MainGerman Centre for Cardiovascular Research (DZHK), Partner Site Rhine-MainBioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung ResearchFootprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development datasets.https://doi.org/10.1038/s41467-020-18035-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mette Bentsen Philipp Goymann Hendrik Schultheis Kathrin Klee Anastasiia Petrova René Wiegandt Annika Fust Jens Preussner Carsten Kuenne Thomas Braun Johnny Kim Mario Looso
spellingShingle	Mette Bentsen Philipp Goymann Hendrik Schultheis Kathrin Klee Anastasiia Petrova René Wiegandt Annika Fust Jens Preussner Carsten Kuenne Thomas Braun Johnny Kim Mario Looso ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation Nature Communications
author_facet	Mette Bentsen Philipp Goymann Hendrik Schultheis Kathrin Klee Anastasiia Petrova René Wiegandt Annika Fust Jens Preussner Carsten Kuenne Thomas Braun Johnny Kim Mario Looso
author_sort	Mette Bentsen
title	ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
title_short	ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
title_full	ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
title_fullStr	ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
title_full_unstemmed	ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
title_sort	atac-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibility profiles and apply it to zygotic development datasets.
url	https://doi.org/10.1038/s41467-020-18035-1
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ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation

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